4′-Fluoro-2′-hydroxyacetophenone
نویسندگان
چکیده
The title compound, C(8)H(7)FO(2), crystallizes as discrete mol-ecules, the conformation of which may be influenced by an intra-molecular hydr-oxy-carbonyl O-H⋯O hydrogen bond.
منابع مشابه
Unstrained C–C bond activation and directed fluorination through photocatalytically-generated radical cations† †Electronic supplementary information (ESI) available: NMR spectra and computational data. See DOI: 10.1039/c5sc01973g Click here for additional data file.
General: [S:2] Representative procedures: [S:3] Characterization data: 6-fluoro-6-phenyl-hexanoic acid (1): [S:4, S:10-S:12] methyl 6-fluoro-6-phenylhexanoate (2): [S:4, S:13-S:15] 6-fluoro-6-phenylhexan-1-ol (3): [S:4, S:16-S:18] 6-fluoro-6-(p-tolyl)hexanoic acid (4): [S:5, S:19-S:21] 6-(4-(tert-butyl)phenyl)-6-fluorohexanoic acid (5): [S:5, S:22-S:24] 6-fluoro-6-(4-fluoro)phenyl-hexanoic acid...
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In the title compound, C(17)H(12)F(2)N(2)OS, the planar thia-zole ring (r.m.s. deviation = 0.012 Å) makes dihedral angles of 15.08 (9) and 81.81 (6)° with the 4-fluoro-phenyl and 2-fluoro-phenyl rings, respectively. The 2-fluoro-phenyl ring is disordered over two orientations with site-occupancy factors of 0.810 (3) and 0.190 (3). The structure contains inter-molecular C-H⋯O hydrogen bonds.
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The synthesis of (2S)-2-benzyloxymethyl-3-(2-fluoro-4-methoxyphenyl)- propionic acid, (2S)-2-benzyloxymethyl-3-(2-fluoro-4-methylphenyl)propionic acid and (2S)-2-benzyl-oxymethyl-3-(2,4-dimethylphenyl)propionic acid has been achieved by TiCl4 mediated alkylation of the corresponding (4R)-4-benzyl-3-[3-(2-fluoro-4-methoxyphenyl-, 2-fluoro-4-methylphenyl-, 2,4- dimethylphenyl-)propionyl]-2-oxazol...
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Based on a literature precedent, preparation of methyl 4-azido-3,4,6-trideoxy-3-fluoro-alpha-D-mannopyranoside (18) was attempted via fluorination of methyl 4-azido-2-O-benzyl-4,6-dideoxy-alpha-D-altropyranoside with diethylaminosulfur trifluoride (DAST). Contrary to expectations, the reaction took place with retention of configuration at the site of the fluorination yielding methyl 4-azido-2-O...
متن کاملcatena-Poly[[diaquacobalt(II)]-bis(μ-4-fluorobenzoato-κ2 O:O′)]
The hydro-thermal reaction of CoCO(3) and 4-fluoro-benzoic acid afforded the title Co(II) complex, [Co(C(7)H(4)FO(2))(2)(H(2)O)(2)](n). The Co(II) atom is located on an inversion center and is coordinated by six O atoms from two water mol-ecules and four μ(2)-carboxyl-ate groups of 4-fluoro-benzoate anions, forming a distorted CoO(6) octa-hedron, with Co-O bond lengths in the range 2.071 (2)-2....
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